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En302014

Omeros Announces Positive Results From Phase 2a Trial Of Oms824 In Patients With Schizophrenia

 Omeros announces positive results from Phase 2a trial of OMS824 in patients with schizophreniaOmeros announces positive results from Phase 2a trial of OMS824 in patients with schizophreniaPublished on January 29, 2014 at 8:04 AM · No CommentsOmeros Corporation (NASDAQ: OMER) today announced positive results from a Phase 2a clinical trial of OMS824, the company's phosphodiesterase 10 (PDE10) inhibitor, in which the drug was well tolerated and demonstrated comparable systemic pharmacokinetics when administered alone and concomitantly with approved antipsychotic agents in patients with schizophrenia . OMS824 selectively inhibits PDE10, an enzyme expressed in areas of the brain linked to a wide range of diseases that affect cognition, including schizophrenia and Huntington's disease.In this Phase 2a randomized, double-blind, placebo-controlled trial, OMS824 was administered at two dose levels for two weeks to psychiatrically stable patients whose antipsychotic medications were temporarily discontinued or who continued their usual antipsychotic regimen. The trial enrolled 33 patients, and the results showed that OMS824 was well tolerated, with mild or moderate adverse events that were self-limited and resolved during the treatment period. The tolerability and pharmacokinetics of OMS824 were not affected by concomitant antipsychotic medications, allowing the drug to be developed as both a monotherapy and as adjunctive therapy in combination with currently approved antipsychotics. The plasma concentrations of OMS824 in the high-dose cohort were similar to levels that corresponded to greater than 60 percent target occupancy of PDE10 in a Phase 1 positron emission tomography (PET) trial. Given the small sample size, efficacy conclusions cannot be drawn but the data support continued development in schizophrenia and other neuropsychiatric conditions.The positive results from this Phase 2a trial suggest that dose adjustment will not be necessary when OMS824 is administered in combination with standard antipsychotic medications. Future Phase 2 and Phase 3 clinical trials in Omeros' schizophrenia program may evaluate OMS824 both as a single agent and as adjunctive treatment for cognitive impairment, acute exacerbation of symptoms, and/or inadequate response to antipsychotic medications.

We Think That Is Because Neural Replay Has Been Triggered While You Sleep.



visit this website http://www.news-medical.net/news/20140129/Omeros-announces-positive-results-from-Phase-2a-trial-of-OMS824-in-patients-with-schizophrenia.aspx



Natus Medical reports revenue of $90.6 million in fourth quarter 2013



 The Company's cash and cash equivalents increased $12 million to $56.1 million during the quarter while total debt was reduced by $10 million. "I am very pleased to report our fourth quarter results. We exceeded our revenue and earnings guidance and achieved record profitability. Our non-GAAP operating profit margin of 19.1% was extremely satisfying. As a result, we have established a new long term annual non-GAAP operating profit margin goal of 20%," said Jim Hawkins, President and Chief Executive Officer of the Company. "Our international revenues were higher than expected during the quarter with solid growth in the Pacific Rim and improving sales in Europe, while our domestic business remained stable." continued Mr. Hawkins. "The record 2013 results were highlighted by non-GAAP earnings growth of 61% to $1.03. Other major achievements include significantly improving operating margins, the successful integration of the Nicolet and Grass acquisitions and the reorganization of the Company into two business units - Neurology and Newborn Care," Hawkins added.

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REM sleep, memory and depression: an interview with Dr Penny Lewis, University of Manchester



 For example, if you learned two lists of words, say words that were read aloud, and then you heard one list read aloud to you again while you were asleep, you would have a better memory of the list that was read to you in you sleep if you were tested on both lists the next day. We think that is because neural replay has been triggered while you sleep. This is actually a very old idea. However, the current work on this involves several really high profile scientific papers showing that this is really true, and the work that has done also allows us to understand why. We know that it?s about triggering this neural activity and strengthening up representations while you sleep. It is has been proposed that people who are depressed may be having too much REM. Please could you explain the reasoning behind this theory? Well, it?s not a theory - it?s an empirical observation that many people who are depressed have excessive amounts of REM, we know that.

visit our website http://www.news-medical.net/news/20140129/REM-sleep-memory-and-depression-an-interview-with-Dr-Penny-Lewis-University-of-Manchester.aspx


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En292014

No Respect For 'regular Doctors'



She Was Stunned To Learn That Her Problems Were Caused By Heart Disease.



 With tens of millions of Americans becoming insured for the first time, we need primary care doctors now more than ever. Acknowledging this need, the Affordable Care Act is testing innovative new payment mechanisms to encourage and reward effective primary care, the most notable of which is the formation of Accountable Care Organizations. Traditionally, primary care doctors have been paid on a "fee for service" basis, meaning that physicians are reimbursed predetermined amounts for the particular service they provided. This payment mechanism gave primary care doctors an incentive to provide a long list of services, whether necessary or not, just to scrape by. In the new model, spearheaded by Medicare, doctors are encouraged to form Accountable Care Organizations where doctors will be rewarded not just for services provided, but also for value added to the patient. Appreciating that quality primary care has the power to prevent expensive hospitalizations and trips to the emergency room, physicians participating in an ACO can receive a portion of the money that insurance companies save as a result of their services. This new model, if successful, has the potential to both reemphasize our health system around primary care and curb the rising cost of health care.

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Heart disease didn't stop her



 At 6 foot 5, Cox was wearing 5XL T-shirts and size 50 jeans. He couldn't stop eating. His mornings began with two breakfast sandwiches and two jelly doughnuts. At night, Cox ate candy and stole the snacks his kids, then 2, 3 and 5 years old, were supposed to take to school the next day. The junk food binges put a strain on his body, the family's food budget and his relationships.

original site http://rss.cnn.com/~r/rss/cnn_health/~3/0nH0M_aJXx0/index.html



Coach drops 132 pounds



 She didn't know what to expect; for years doctors had shrugged off her symptoms. She was stunned to learn that her problems were caused by heart disease. The new mother had a left ventricular non-compaction cardiomyopathy , a congenital disorder that affects a small percentage of people. With LVNC, muscle fibers in the lower left chamber of the heart do not turn into solid muscle as they should during normal development. Instead the fibers remain and interfere with the heart's function. Kern's cardiologist suspected that she also had Catecholaminergic Polymorphic Ventricular Tachycardia , an abnormal heart rhythm disorder that could potentially cause sudden cardiac arrest. The diagnosis sent her into a spiral of depression. "I thought I was going to die," she says.

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En282014

Good News

 [ Post a Response | The Coeliac, D H and Gluten Free Message Board ]When posting messages that contain useful information please only use smilies at the start and end of the message to make it easier to copy it to the supplementary board. It is even more helpful if you post a copy of useful information on the supp board yourself.Sandwich thins again. Great for sandwich toaster.

However, They Seem To Have Been Taken Back To The Bad Old Days.

Posted by Judy on 27/1/2014, 19:12:3592.19.132.x  Sorry if this has already been on but today we discovered that they make really good toasties in the sandwich toaster. I bought a new toasted sandwich maker after dx but it didn't work with GF bread so today we tried it with the sandwich thins. I buttered the outsides and put one half in the toaster, then the filling and then the top. Went down a treat.

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Sandwich thins again. Great for sandwich toaster.



 The Coeliac, D H and Gluten Free Message Board  

It Is Even More Helpful If You Post A Copy Of Useful Information On The Supp Board Yourself.

   
 [ Post a Response | The Coeliac, D H and Gluten Free Message Board ]       When posting messages that contain useful information please only use smilies at the start and end of the message to make it easier to copy it to the supplementary board. It is even more helpful if you post a copy of useful information on the supp board yourself.Kallo rice cakesPosted by PAM Scotland on 26/1/2014, 22:32:2882.27.6.xHas anyone tried the rice cakes in the new packaging? Has anyone found them soft and tasteless?Since diagnosis over 10 years ago, I have found that rice cakes have vastly improved. However, they seem to have been taken back to the bad old days.I'm interested to hear the views of others.

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Where can I buy GF pasty in the shops?



 The Coeliac, D H and Gluten Free Message Board [ Post a Response | The Coeliac, D H and Gluten Free Message Board ] When posting messages that contain useful information please only use smilies at the start and end of the message to make it easier to copy it to the supplementary board. It is even more helpful if you post a copy of useful information on the supp board yourself. good news Posted by honorary coeliac mum on 27/1/2014, 21:38:50 86.6.154.x Just to share some really good news. My son has just picked up his blood results for his first annual review, and everything is within normal range again and the coeliac antibodies (EMA) are negative (at the start of all this a year ago he was quite severely anaemic, low iron stores, low Vit D, sky high enzymes).

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Kallo rice cakes



 The Coeliac, D H and Gluten Free Message Board[ Post a Response | The Coeliac, D H and Gluten Free Message Board ]When posting messages that contain useful information please only use smilies at the start and end of the message to make it easier to copy it to the supplementary board. It is even more helpful if you post a copy of useful information on the supp board yourself.Where can I buy GF pasty in the shops?Posted by Jack on 27/1/2014, 16:24:4882.30.199.x

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En272014

Dramatic Rise In Flu Deaths Reported By California Health Officials

   

In November, When He Turns 26, He'll No Longer Be Covered By His Mother's Health Plan.

  
 That would put this year's number of flu fatalities so far at 146. At this time last year, nine deaths had been confirmed, and only 106 were confirmed by the end of the season.  "So far we have a much more severe season," said state epidemiologist Dr. Gil Chavez in a conference call with reporters Friday. He said that flu activity in California remained "widespread."  In part, the gap between this year's deaths and the number of deaths at this time last year is because this year's season struck early, Chavez said. However, this year's predominant flu strain is H1N1 "swine flu," which is more deadly than other strains.

read full article http://www.latimes.com/health/la-me-ln-california-flu-deaths-up-20140124,0,6796237.story?track=rss

 

Examining your health insurance options under Obamacare

      

In California, Go To The Covered California Website Or Call The Health Marketplace At (800) 300-1506.



 Also Full coverage: Obamacare rolls out The math of President Obama 's Affordable Care Act works only if millions of healthy consumers start paying into the system to offset the bills racked up by sicker people who can't be turned away. Persuading twentysomethings won't be easy. Max Halpern, a 25-year-old San Diego law student, is healthy and doesn't spend much time worrying about his next doctor's appointment. In November, when he turns 26, he'll no longer be covered by his mother's health plan. The new law mandates coverage for most Americans, but the penalties for opting out can be cheap ? less than $100 in some cases.

find stuff http://www.latimes.com/health/la-fi-health-law-young-vs-old-20131001,0,2616906.story?track=rss



New health insurance exchanges want young, healthy people



 Enrollment for the state exchange runs through March 31. Medi-Cal, the state's Medicaid program, accepts applicants year round. Where do I go to enroll? In California, go to the Covered California website or call the health marketplace at (800) 300-1506. The state can also refer you to community groups, insurance agents and government offices that offer enrollment help in person.

go now ok http://www.latimes.com/health/la-fi-healthcare-watch-20130929,0,5399224.story?track=rss


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En262014

Dramatic Rise In Flu Deaths Reported By California Health Officials

       Like shoppers queuing up for bargains on Black Friday, people such as 52-year-old James Craig, an uninsured day laborer, say they can't wait to get their insurance cards. "I think Obamacare is the greatest thing ever," said the Los Angeles resident, who said he suffers from high blood pressure and hasn't seen a doctor in years. Also Full coverage: Obamacare rolls out The math of President Obama 's Affordable Care Act works only if millions of healthy consumers start paying into the system to offset the bills racked up by sicker people who can't be turned away. Persuading twentysomethings won't be easy. Max Halpern, a 25-year-old San Diego law student, is healthy and doesn't spend much time worrying about his next doctor's appointment. In November, when he turns 26, he'll no longer be covered by his mother's health plan.

find more info http://www.latimes.com/health/la-fi-health-law-young-vs-old-20131001,0,2616906.story?track=rss

 

Examining your health insurance options under Obamacare





Max Halpern, A 25-year-old San Diego Law Student, Is Healthy And Doesn't Spend Much Time Worrying About His Next Doctor's Appointment.

 Please share your comments or ask questions at [email protected] . Submissions must include names and phone numbers. Also Healthcare law comes to California Do I need to do anything right now? You have time to consider your options.

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New health insurance exchanges want young, healthy people



 Dramatic rise in flu deaths reported by California health officials Comments 1 The Regional Medical Center of San Jose set up a 'flu tent' outside an emergency room to treat patients with flu-like symptoms in San Jose. (EPA/JOHN G. MABANGLO / January 24, 2014) By Soumya Karlamangla January 24, 2014, 12:09 p.m. State health officials reported Friday that California influenza deaths this flu season have doubled to 95, with an additional 51 cases likely to be confirmed next week.

find out this here http://www.latimes.com/health/la-me-ln-california-flu-deaths-up-20140124,0,6796237.story?track=rss


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